What is the meaning of ET in medical terms?
What is the meaning of ET in medical terms?
By. Essential thrombocythemia (ET) is a rare disorder in which the bone marrow produces too many platelets. ET is part of a category of diseases known as myeloproliferative disorders, a group of disorders characterized by the increased production of a particular type of blood cell.
Whats et means?
Eastern Time
What is ET diagnosis?
Essential Thrombocythemia (ET) is a chronic myeloproliferative neoplasm (MPN) characterized by an increased number of platelets in the blood.
What is ET in hematology?
Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by an increased platelet count, megakaryocytic hyperplasia, and a hemorrhagic or microvascular thrombotic tendency. Symptoms and signs may include weakness, headaches, paresthesias, bleeding, and erythromelalgia with digital ischemia.
How long can you live with ET?
The condition usually affects people in middle age, although it can be seen in younger patients, especially in women less than 40 years old. Patients with ET have an excellent chance of living a normal life span if they are properly monitored and treated as necessary.
Is there a cure for ET?
Although there’s no cure for essential thrombocythemia, treatments can control symptoms and reduce the risk of complications. Life span is expected to be normal despite the disease. Treatment of essential thrombocythemia depends on your risk of blood clots or bleeding episodes.
How long can you live with essential thrombocythemia?
The life expectancy of patients with essential thrombocytosis (primary thrombocythemia) is nearly that of the healthy population. Median survival is approximately 20 years. For patients younger than age 60 years, median survival is 33 years.
How serious is essential thrombocythemia?
Essential thrombocythemia is a chronic disease with no cure. If you have a mild form of the disease, you may not need treatment. If you have severe symptoms, you may need medicine that lowers your platelet count, blood thinners or both.
Can essential thrombocythemia turn into leukemia?
Essential thrombocythemia patients develop acute myeloid leukemia (AML) at a rate of 1-4% during a median follow-up of 7-10 years. The risk increases with advanced age, anemia, platelet count ≥ 1000 × 10(9)/l, the presence of ≥ 2 somatic mutations and after the first decade of diagnosis.
Does essential thrombocythemia affect immune system?
The reason that mutations in the CALR and TET2 genes cause essential thrombocythemia is not known. The CALR gene provides instructions for creating a protein called calreticulin that has many functions, such as aiding the functioning of the immune system and wound healing.
Is essential thrombocythemia a rare disease?
Essential thrombocythemia, also known as ET, is a rare disease. The most important first fact about ET: on average, people with ET have a normal life expectancy. Patients with ET have increased numbers of platelets.
Can stress cause essential thrombocythemia?
Although altered lymphocyte and immune functions have been known in patients with PTSD, essential thrombocytosis is a rare phenomenon. This report has introduced an individual exposure to traumatic stress which has currently lower social support with higher rates of post-traumatic stress and associated disorders.
Is essential thrombocythemia progressive?
Essential thrombocythemia is sometimes described as a slowly progressive disorder with long asymptomatic periods punctuated by thrombotic or hemorrhagic events.
Is essential thrombocythemia inherited?
Most cases of essential thrombocythemia are not inherited. Instead, the condition arises from gene mutations that occur in early blood-forming cells after conception. These alterations are called somatic mutations.
Is essential thrombocythemia malignant?
ET belongs to a group of conditions called myeloproliferative neoplasms (MPNs). For many years there has been some discussion about whether or not these conditions were cancer. But MPNs are classed by the World Health Organisation as a blood cancers.
How do you test for essential thrombocythemia?
Blood tests and sometimes a bone marrow test are used to diagnose essential thrombocythemia (ET). Your doctor may suspect ET as a result of a routine blood test showing a higher-than-normal platelet count.
What are the symptoms of thrombocythemia?
Symptoms of thrombocythemia include:
- Blood clots in arteries and veins, most often in the hands, feet, and brain.
- Bruising easily.
- Bleeding from the nose, gums, and GI (gastrointestinal) tract.
- Bloody stools.
- Bleeding after injury or surgery.
- Weakness.
- Headache and dizziness.
- Swollen lymph nodes.
What if WBC and platelets are high?
High WBC counts often occur in conditions such as chronic inflammation or myeloproliferative disorders. Low numbers of platelets can be evident in disorders like immune thrombocytopenia (ITP). Conditions associated with high platelet counts can include reactive thrombocytosis or essential thrombocythemia.
What does it mean when my platelets are high?
A high platelet count may be referred to as thrombocytosis. This is usually the result of an existing condition (also called secondary or reactive thrombocytosis), such as: Cancer, most commonly lung cancer, gastrointestinal cancer, ovarian cancer, breast cancer, or lymphoma.