What are examples of Isosteres?

What are examples of Isosteres?

Isosteres are atoms, molecules, or ions of similar size, containing the same number of atoms and valence electrons. Examples: N2 and CO, N2O and CO2 etc.

Which given pair is Isosteres?

ISOSTERES are atoms or molecules of similar size containing the same number of atoms and valence electrons. Thus the best example of isosteres are CO and N. Thus the answer is (2).

What is meant by Bioisosterism?

A bioisostere is a compound resulting from the exchange of an atom or of a group of atoms with another, broadly similar, atom or group of atoms. The objective of a bioisosteric replacement is to create a new compound with similar biological properties to the parent compound. (See also isostere.)

What is ring equivalent Bioisosteres?

Bioisosteres – A bioisostere is a molecule resulting from the exchange of an atom or of a group of atoms with an alternative, broadly similar, atom or group of atoms. The bioisosteric replacement may be physicochemically or topologically based. …

What is Isosteres chemistry?

Isosteres are atoms, molecules, or ions of similar size containing the same number of atoms and valence electrons. one of two or more substances (as carbon monoxide and molecular n… Show more….

Who introduced concept of Bioisosteric group?

Classical bioisosteres Classical bioisosterism was originally formulated by James Moir and refined by Irving Langmuir as a response to the observation that different atoms with the same valence electron structure had similar biological properties.

What is meant by Pharmacophore?

Definition: A Pharmacophore is an ensemble of steric, electrostatic and hydrophobic properties which is essential for optimal supramolecular interactions with a biolocial receptor, to modulate or inhibit a biological effect.

Is used for Bioisosteric replacement of benzene?

The replacement of para-substituted benzenes with saturated bi- and polycyclic bioisosteres – bicyclo[1.1. 1]pentane, bicyclo[2.2. 2]octane and cubane, – often increases the potency, selectivity and metabolic stability of bioactive compounds.

Which is used for Bioisosteric replacement of benzene?

Which of the following is a pair of isoelectronic species?

Explanation: Number of electrons in CIO₂⁻ = 17+ 16+ 1 = 34 electrons. Number of electrons in CIF₂⁺ = 17+ 18- 1 = 34 electrons. Hence, CIO₂⁻ and CIF₂⁺ are isoelectronic species.

Which one of the following pairs are isoelectronic and isotopic?

Atomic number of potassium is 19 so number of electron in 39K+ and 40K+ is 18. So both are isoelectronic species. Isotopes are defined as atoms of same element having the same atomic number, but different mass numbers. These atoms contain an equal number of protons and electrons, but a different number of neutrons….

Which of the following pair illustrates an isoelectronic pair?

Solution : BrO-2 and BrF+2 ions are isoelectronic in nature. Both have (35+17)=52 electrons….

Which of the following is isoelectronic with ca2+?

question_answer Answers(2) S⁻², Cl⁻, Ar, K⁺, Sc⁺³ are the species which contains same number of electrons (Iso-electronic species) as Ca⁺²….

Is CA Isoelectronic with AR?

Isoelectronic means that the entities (atoms, ions, molecules) in question have the same electronic structure and same number of valence electrons. For atoms/ions: Therefore, K+ and Ar are said to be isoelectronic. Ca2+ is also electronic with Ar, for example, and so is Cl-.

Which is isoelectronic with AR?

The chemical species isoelectronic to Ar are phosphide ion (P3− ), sulfide ion (S2− ), chloride ion (Cl− ),…

How many 3d electrons are in fe3+?

Ok. There is only one unpaired electron in 3d orbital which contains only 5 electrons. 1s2, 2s2, 2p6, 3s2, 3p6, 3d5. Two electrons are removed from 4s orbital and one electron is removed from 3d orbital.

What do you know about diagonal relationship?

A diagonal relationship is said to exist between certain pairs of diagonally adjacent elements in the second and third periods (first 20 elements) of the periodic table. Moving rightward across the period decreases the atomic radii of atoms, while moving down the group will increase the atomic radii.